Mongersen, an Oral SMAD7 Antisense Oligonucleotide, and Crohn’s Disease
نویسندگان
چکیده
Copyright © 2015 Massachusetts Medical Society. BACKGROUND Crohn’s disease–related inflammation is characterized by reduced activity of the immunosuppressive cytokine transforming growth factor β1 (TGF-β1) due to high levels of SMAD7, an inhibitor of TGF-β1 signaling. Preclinical studies and a phase 1 study have shown that an oral SMAD7 antisense oligonucleotide, mongersen, targets ileal and colonic SMAD7.
منابع مشابه
Mongersen, an Oral SMAD7 Antisense Oligonucleotide, and Crohn's Disease.
BACKGROUND Crohn's disease-related inflammation is characterized by reduced activity of the immunosuppressive cytokine transforming growth factor β1 (TGF-β1) due to high levels of SMAD7, an inhibitor of TGF-β1 signaling. Preclinical studies and a phase 1 study have shown that an oral SMAD7 antisense oligonucleotide, mongersen, targets ileal and colonic SMAD7. METHODS In a double-blind, placeb...
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